Endocrine disrupting Chemicals - 2012

Borstkanker, neurotoxiteit (ontwikkeling hersenen bij kinderen), schildklier, cognitieve- en gedragsstoornissen, immuunsysteem.

Te veel PCB's

Hoe kan ontkend worden dat de implantaten niet schadelijk zijn voor het immuunsysteem en waarom wordt niet de moeite genomen dit te onderzoeken, terwijl in een bloedonderzoek van een patiënt die erg ziek is door gescheurde implantaten, een véél te hoge pcb-waarde werd gemeten. (Dit onderzoek vond plaats op eigen initiatief van de patiënt)

PCB's: 4 maal de maximale referentiewaarde (mag zijn 1-4ng/ml) deze was 16ng/ml

Deze patiënte was/is vegetarisch en heeft nooit vis gegeten, dat de hoge pcb waarde zou kunnen verklaren.

Hexaan: 2 maal de maximale referentiewaarde (mag zijn 2.8-7.9mg/ml) deze was 16.4 mg/ml

Xyleen: ruim 3 maal de maximale referentiewaarde (mag zijn 1-2.9mg/ml) deze was 9.2 mg/m l

Onderzoeken van de WHO

Exposure to dioxin and dioxin-like substances; A major public health concern

Polychlorinated biphenyls: human health aspects

Humans may be exposed to PCBs by inhaling contaminated air and ingesting contaminated water and food. In 1978, the estimated dietary intake of PCBs by adults in the USA was 0.027 µg/kg body weight per day, but it declined to 0.0005 µg/kg body weight per day in 1982-1984 and <0.001 µg/kg body weight per day for the period 1986 - 1991.

Dioxins and their effects on human health

Extensive stores of PCB-based waste industrial oils, many with high levels of PCDFs, exist throughout the world. Long-term storage and improper disposal of this material may result in dioxin release into the environment and the contamination of human and animal food supplies. PCB-based waste is not easily disposed of without contamination of the environment and human populations. Such material needs to be treated as hazardous waste and is best destroyed by high temperature incineration.

Safety evaluation of certain food additives and contaminants

Polychlorinates Dibenzodioxins

Polychlorinated Dibenzofurans

Coplanar polychlorinated Biphenyls

Europese Commissie

Maximum levels set for dioxins and PCB's in feed and food

Questions and answers on Dioxins and PCBs

What is the problem with dioxins and PCBs?

Dioxins and PCBs are toxic chemicals that can provoke serious health effects such as cancer, hormone disruption, reduced ability to reproduce, skin toxicity and immune system disorders. They are not soluble in water and are highly soluble in fat. This means that they bind to sediment and organic matter in the environment and are absorbed in animal and human fatty tissue. In addition they are not biodegradable so they are persistent and bio-accumulate in the food chain. This means that once released into the environment, via air or via water, they pile up in the fat tissue of animals and humans, causing toxicological damage over time.

What are the WHO-TEQs, used to set the maximum limits for dioxins and dioxin-like PCBs?

The EU maximum levels set for dioxins and dioxin-like PCBs are based on the World Health Organisation (WHO) toxic equivalents (TEQs), which are used to express the toxicological concentrations of these chemicals and enable risk assessments to be carried out.

European Commission - Dioxins and PCBs

The dietary exposure to dioxins and dioxin-like PCBs exceeds the Tolerable Weekly Intake (TWI) or the Tolerable Daily Intake (TDI) for a considerable part of the European population: the Scientific Committee on Food (SCF) of the EU adopted on 30 May 2001 an opinion on the Risk Assessment of dioxins and dioxin-like PCBs in food. The Committee established a group TWI for dioxins and dioxin-like PCBs of 14 pg Toxic Equivalent (WHO-TEQ) /kg bodyweight. This TWI is in line with the provisional Tolerable Monthly Intake of 70 pg/kg bodyweight/month established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) at its fifty-seventh meeting (Rome, 5-14 June 2001) and concurs with the lower end of the range TDI of 1-4 pg WHO-TEQ/kg body weight, established by the World Health Organisation (WHO) Consultation in 1998. Representative recent dietary intake data indicate that the average dietary intakes of dioxins and dioxin-like PCBs in the EU is in the range of 1.2-3 pg/kg bodyweight and day which means that a considerable part of the European population would still exceed the TWI or TDI.

Eur-lex.europa - PCB's 2004.

Eur-lex.europa - PCB's 2007

What measures have been taken at EU level in the past 10 years to tackle contamination by dioxin/PCB?

Wetenschappelijke onderzoeken PCB's

De effecten van perinatale blootstelling aan PCB's op de immuunrespons

De effecten van perinatale blootstelling aan PCB's op de immuunrespons

Blootstelling aan PCB’s zou in deze gevallen een risico kunnen vormen als het functioneren van het immuunsysteem ook wordt aangetast door andere factoren, zoals vroegtijdige geboorte, chronische ziekten of andere aandoeningen

De meeste chloorkoolwaterstoffen worden aangetroffen in dierlijke producten zoals vis, vlees, en melkproducten. Het is dus aannemelijk dat deze producten het meest bijdragen aan de hoeveelheid PCB’s waar mensen aan worden blootgesteld (Covaci et al., 2002).